metacore analytical software (GeneGo Inc)
90
Structured Review
GeneGo Inc
metacore analytical software
Metacore Analytical Software, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/metacore+analytical+software/metacore+analytical+software/us11414463-835-96-95
Average 90 stars, based on 1 article reviews
Metacore Analytical Software, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/metacore+analytical+software/metacore+analytical+software/us11414463-835-96-95
Average 90 stars, based on 1 article reviews
metacore analytical software - by Bioz Stars,
2026-11
90/100 stars
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Significance Assay:Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Regulatory processes/lmmune system response pathway P-value Significant* Total** Immune response_IL-10 signaling pathway 0.00125 10 26 Immune response_IL-9 signaling pathway 0.00592 11 36 Immune response_HMGB1/RAGE signaling pathway 0.00832 14 53 Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 co-stimulation in activation 0.03611 10 40 of NF-kB Immune response_Regulation of T cell function by CTLA-4 0.04598 9 36 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: .. TABLE S5 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28 d. Regulatory processes/ Immune system response pathway P-value Significant* Total** Immune response_IL-10 signaling 0.00125 10 26 pathway Immune response_IL-9 signaling 0.00592 11 36 pathway Immune response_HMGB1/RAGE 0.00832 14 53 signaling pathway Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 0.03611 10 40 co-stimulation in activation of NF-kB Immune response_Regulation of T cell 0.04598 9 36 function by CTLA-4 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Activation Assay:Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Regulatory processes/lmmune system response pathway P-value Significant* Total** Immune response_IL-10 signaling pathway 0.00125 10 26 Immune response_IL-9 signaling pathway 0.00592 11 36 Immune response_HMGB1/RAGE signaling pathway 0.00832 14 53 Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 co-stimulation in activation 0.03611 10 40 of NF-kB Immune response_Regulation of T cell function by CTLA-4 0.04598 9 36 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: .. TABLE S5 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28 d. Regulatory processes/ Immune system response pathway P-value Significant* Total** Immune response_IL-10 signaling 0.00125 10 26 pathway Immune response_IL-9 signaling 0.00592 11 36 pathway Immune response_HMGB1/RAGE 0.00832 14 53 signaling pathway Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 0.03611 10 40 co-stimulation in activation of NF-kB Immune response_Regulation of T cell 0.04598 9 36 function by CTLA-4 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Cell Function Assay:Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Regulatory processes/lmmune system response pathway P-value Significant* Total** Immune response_IL-10 signaling pathway 0.00125 10 26 Immune response_IL-9 signaling pathway 0.00592 11 36 Immune response_HMGB1/RAGE signaling pathway 0.00832 14 53 Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 co-stimulation in activation 0.03611 10 40 of NF-kB Immune response_Regulation of T cell function by CTLA-4 0.04598 9 36 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Transduction:Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Regulatory processes/lmmune system response pathway P-value Significant* Total** Immune response_IL-10 signaling pathway 0.00125 10 26 Immune response_IL-9 signaling pathway 0.00592 11 36 Immune response_HMGB1/RAGE signaling pathway 0.00832 14 53 Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 co-stimulation in activation 0.03611 10 40 of NF-kB Immune response_Regulation of T cell function by CTLA-4 0.04598 9 36 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: .. TABLE S5 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28 d. Regulatory processes/ Immune system response pathway P-value Significant* Total** Immune response_IL-10 signaling 0.00125 10 26 pathway Immune response_IL-9 signaling 0.00592 11 36 pathway Immune response_HMGB1/RAGE 0.00832 14 53 signaling pathway Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 0.03611 10 40 co-stimulation in activation of NF-kB Immune response_Regulation of T cell 0.04598 9 36 function by CTLA-4 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Software:Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Regulatory processes/lmmune system response pathway P-value Significant* Total** Immune response_IL-10 signaling pathway 0.00125 10 26 Immune response_IL-9 signaling pathway 0.00592 11 36 Immune response_HMGB1/RAGE signaling pathway 0.00832 14 53 Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 co-stimulation in activation 0.03611 10 40 of NF-kB Immune response_Regulation of T cell function by CTLA-4 0.04598 9 36 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: .. TABLE S5 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28 d. Regulatory processes/ Immune system response pathway P-value Significant* Total** Immune response_IL-10 signaling 0.00125 10 26 pathway Immune response_IL-9 signaling 0.00592 11 36 pathway Immune response_HMGB1/RAGE 0.00832 14 53 signaling pathway Immune response_BCR pathway 0.00992 14 54 Development_GM-CSF signaling 0.01258 13 50 Development_PEDF signaling 0.02618 12 49 Immune response_IL-5 signalling 0.02840 11 44 Immune response_TCR and CD28 0.03611 10 40 co-stimulation in activation of NF-kB Immune response_Regulation of T cell 0.04598 9 36 function by CTLA-4 Immune response_CD40 signaling 0.04796 14 65 Signal transduction_JNK pathway 0.04921 10 42 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28d. .. Differentially expressed genes (P<0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: TABLE S6 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between TLR5 KO mice and WT mice, mono-colonized with R. hominis. .. Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: .. TABLE S5 Immune system response pathway analysis of transcripts differentially expressed in the ascending colon between R. hominis treated mice and germfree mice at 28 d. Differentially expressed genes (P < 0.05) were imported into other:Article Title: Polypeptide and immune modulation Article Snippet: # Maps pValue Ratio 1 Immune response_IL-9 signaling pathway 0.00001 7 36 2 Immune response_Histamine signaling in dendritic cells 0.00008 7 50 3 Immune response_HMGB1/RAGE signaling pathway 0.00012 7 53 4 Immune response_IL-6 signaling pathway 0.00046 5 31 5 Immune response_Histamine H1 receptor signaling in immune 0.00052 6 48 response 6 Immune response_Oncostatin M signaling via MAPK in mouse 0.00082 5 35 cells 7 Immune response_Oncostatin M signaling via MAPK in human 0.00107 5 37 cells 8 Signal transduction_JNK pathway 0.00191 5 42 9 Immune response_IL-7 signaling in B lymphocytes 0.00213 5 43 10 Immune response_Signaling pathway mediated by IL-6 and IL-1 0.00362 4 30 11 Development_GM-CSF signaling 0.00415 5 50 12 Immune response_T cell receptor signaling pathway 0.00492 5 52 13 Chemotaxis_Leukocyte chemotaxis 0.00528 6 75 14 Immune response_CCL2 signaling 0.00579 5 54 15 Immune response_CD28 signaling 0.00579 5 54 16 Immune response_Role of DAP12 receptors in NK cells 0.00579 5 54 17 Immune response_Fc epsilon RI pathway 0.00626 5 55 18 Immune response_Role of PKR in stress-induced antiviral cell 0.00728 5 57 response 19 Immune response_HMGB1 release from the cell 0.01114 4 41 20 Immune response_IL-15 signaling 0.01176 5 64 21 Immune response_HTR2A-induced activation of cPLA2 0.01313 4 43 22 Immune response_IL-4 signaling pathway 0.01421 4 44 23 Immune response_IL-5 signalling 0.01421 4 44 24 Immune response_Fc gamma R-mediated phagocytosis in 0.01653 4 46 macrophages 25 Immune response_NF-AT signaling and leukocyte interactions 0.01653 4 46 26 Development_PEDF signaling 0.02043 4 49 27 Immune response_IL-2 activation and signaling pathway 0.02043 4 49 28 Immune response_NFAT in immune response 0.02332 4 51 29 Immune response_IL-3 activation and signaling pathway 0.02803 3 31 30 Immune response_BCR pathway 0.02809 4 54 31 Immune response_TLR signaling pathways 0.02809 4 54 32 Immune response_Immunological synapse formation 0.03727 4 59 33 Immune response_Th17 cell differentiation 0.03836 3 35 34 Immune response_Human NKG2D signaling 0.04722 3 38 Differentially expressed genes (P < 0.05) were imported into Article Title: Polypeptide and immune modulation Article Snippet: # Maps pValue Ratio 1 Immune response_IL-9 signaling pathway 0.00001 7 36 2 Immune response_Histamine signaling in dendritic cells 0.00008 7 50 3 Immune response_HMGB1/RAGE signaling pathway 0.00012 7 53 4 Immune response_IL-6 signaling pathway 0.00046 5 31 5 Immune response_Histamine H1 receptor signaling in immune 0.00052 6 48 response 6 Immune response_Oncostatin M signaling via MAPK in mouse cells 0.00082 5 35 7 Immune response_Oncostatin M signaling via MAPK in human cells 0.00107 5 37 8 Signal transduction_JNK pathway 0.00191 5 42 9 Immune response_IL-7 signaling in B lymphocytes 0.00213 5 43 10 Immune response_Signaling pathway mediated by IL-6 and IL-1 0.00362 4 30 11 Development_GM-CSF signaling 0.00415 5 50 12 Immune response_T cell receptor signaling pathway 0.00492 5 52 13 Chemotaxis_Leukocyte chemotaxis 0.00528 6 75 14 Immune response_CCL2 signaling 0.00579 5 54 15 Immune response_CD28 signaling 0.00579 5 54 16 Immune response_Role of DAP12 receptors in NK cells 0.00579 5 54 17 Immune response_Fc epsilon RI pathway 0.00626 5 55 18 Immune response_Role of PKR in stress-induced antiviral cell 0.00728 5 57 response 19 Immune response_HMGB1 release from the cell 0.01114 4 41 20 Immune response_IL-15 signaling 0.01176 5 64 21 Immune response_HTR2A-induced activation of cPLA2 0.01313 4 43 22 Immune response_IL-4 signaling pathway 0.01421 4 44 23 Immune response_IL-5 signalling 0.01421 4 44 24 Immune response_Fc gamma R-mediated phagocytosis in 0.01653 4 46 macrophages 25 Immune response_NF-AT signaling and leukocyte interactions 0.01653 4 46 26 Development_PEDF signaling 0.02043 4 49 27 Immune response_IL-2 activation and signaling pathway 0.02043 4 49 28 Immune response_NFAT in immune response 0.02332 4 51 29 Immune response_IL-3 activation and signaling pathway 0.02803 3 31 30 Immune response_BCR pathway 0.02809 4 54 31 Immune response_TLR signaling pathways 0.02809 4 54 32 Immune response_Immunological synapse formation 0.03727 4 59 33 Immune response_Th17 cell differentiation 0.03836 3 35 34 Immune response_Human NKG2D signaling 0.04722 3 38 Differentially expressed genes (P < 0.05) were imported into |
![Intestine-specific overexpression of LDLR improves glucose metabolism. (A) Real-time PCR was used to validate several targets that we selected based on a microarray study of the duodenum. The targets included Glut1 and several key factors and enzymes of cholesterol metabolism: Ldlr, Npc1l1, and Pcsk9. (B) Heat map and color key for significantly regulated genes related to glucose metabolism in the duodenum. A comparison of transgenic vs wild-type mice is shown. Each cell represents the average log2 fold change. The list was based on the microarray gene expression analysis of the duodenum. (C) List of the statistically significant metabolic networks in the duodenum. A comparison of transgenic vs wild-type mice is shown. These pathways were determined using <t>Metacore™</t> (Thompson Reuters). Most of these networks are related to the metabolism of glucose and other carbohydrates, suggesting that LDLR overexpression affects glucose metabolism of the intestine. (D) Chow-fed C57BL/6-TG(Vil-LDLR) mice had lower fasting blood glucose (FBG) levels compared with controls. (E) Fasting blood glucose levels normalized in transgenic mice fed with a HFHC diet. (F) Blood glucose levels were lower at weaning. These measurements were performed without fasting [random blood glucose (RBG) levels]. Statistics: n = 3 to 15 per group; results are expressed as mean ± SD; one-sample t test for real-time PCR, t test for other comparisons between groups. *P < 0.05. TG, C57BL/6-TG(Vil-LDLR) transgenic mice; WT, wild-type littermate controls.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_9722/pmc06399722/pmc06399722__en.2018-00098f5.jpg)